Gene name:
FBXO45 (FBX45) ;
Protein name:
F-box/SPRY domain-containing protein 1 ;
Alternative:
F-box only protein 45 (hFbxo45) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Forms a complex with MYCBP2 and SKP1 but does not appear to form an authentic SCF (SKP1-CUL1-F-box protein) complex (By similarity). Interacts (via B30.2/SPRY domain) with TP73 (via SAM domain); leading to TP73 ubiquination and degradation by proteasome. Interacts (via SRY domain) with UNC13A; leading to degradation of UNC13A by the proteasome.
Function:
Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation.
Subcellular Location:
Cell junction
synapse
postsynaptic cell membrane
Cell junction
synapse
presynaptic cell membrane
Protein Attributes:
50:
MAAPAPGAGA | ASGGAGCSGG | GAGAGAGSGS | GAAGAGGRLP | SRVLELVFSY |
100:
LELSELRSCA | LVCKHWYRCL | HGDENSEVWR | SLCARSLAEE | ALRTDILCNL |
150:
PSYKAKIRAF | QHAFSTNDCS | RNVYIKKNGF | TLHRNPIAQS | TDGARTKIGF |
200:
SEGRHAWEVW | WEGPLGTVAV | IGIATKRAPM | QCQGYVALLG | SDDQSWGWNL |
250:
VDNNLLHNGE | VNGSFPQCNN | APKYQIGERI | RVILDMEDKT | LAFERGYEFL |
286:
GVAFRGLPKV | CLYPAVSAVY | GNTEVTLVYL | GKPLDG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Human F-box/SPRY domain-containing protein 1
ELISA Kit for Human F-box/SPRY domain-containing protein 1
ELISA Kit for Human F-box/SPRY domain-containing protein 1
CLIA Kit for Human F-box/SPRY domain-containing protein 1
CLIA Kit for Human F-box/SPRY domain-containing protein 1
CLIA Kit for Human F-box/SPRY domain-containing protein 1
Polyclonal Antibody for Human F-box/SPRY domain-containing protein 1
Polyclonal Antibody for Human F-box/SPRY domain-containing protein 1
Polyclonal Antibody for Human F-box/SPRY domain-containing protein 1
Monoclonal Antibody for Human F-box/SPRY domain-containing protein 1
Monoclonal Antibody for Human F-box/SPRY domain-containing protein 1
Monoclonal Antibody for Human F-box/SPRY domain-containing protein 1
Protein for Human F-box/SPRY domain-containing protein 1
Protein for Human F-box/SPRY domain-containing protein 1
Protein for Human F-box/SPRY domain-containing protein 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M.
,
Scherer S.E.
,
Kaul R.
,
Wang J.
,
Yu J.
,
Sudbrak R.
,
Buhay C.J.
,
Chen R.
,
Cree A.
,
Ding Y.
,
Dugan-Rocha S.
,
Gill R.
,
Gunaratne P.
,
Harris R.A.
,
Hawes A.C.
,
Hernandez J.
,
Hodgson A.V.
,
Hume J.
,
Jackson A.
,
Khan Z.M.
,
Kovar-Smith C.
,
Lewis L.R.
,
Lozado R.J.
,
Metzker M.L.
,
Milosavljevic A.
,
Miner G.R.
,
Morgan M.B.
,
Nazareth L.V.
,
Scott G.
,
Sodergren E.
,
Song X.-Z.
,
Steffen D.
,
Wei S.
,
Wheeler D.A.
,
Wright M.W.
,
Worley K.C.
,
Yuan Y.
,
Zhang Z.
,
Adams C.Q.
,
Ansari-Lari M.A.
,
Ayele M.
,
Brown M.J.
,
Chen G.
,
Chen Z.
,
Clendenning J.
,
Clerc-Blankenburg K.P.
,
Chen R.
,
Chen Z.
,
Davis C.
,
Delgado O.
,
Dinh H.H.
,
Dong W.
,
Draper H.
,
Ernst S.
,
Fu G.
,
Gonzalez-Garay M.L.
,
Garcia D.K.
,
Gillett W.
,
Gu J.
,
Hao B.
,
Haugen E.
,
Havlak P.
,
He X.
,
Hennig S.
,
Hu S.
,
Huang W.
,
Jackson L.R.
,
Jacob L.S.
,
Kelly S.H.
,
Kube M.
,
Levy R.
,
Li Z.
,
Liu B.
,
Liu J.
,
Liu W.
,
Lu J.
,
Maheshwari M.
,
Nguyen B.-V.
,
Okwuonu G.O.
,
Palmeiri A.
,
Pasternak S.
,
Perez L.M.
,
Phelps K.A.
,
Plopper F.J.
,
Qiang B.
,
Raymond C.
,
Rodriguez R.
,
Saenphimmachak C.
,
Santibanez J.
,
Shen H.
,
Shen Y.
,
Subramanian S.
,
Tabor P.E.
,
Verduzco D.
,
Waldron L.
,
Wang J.
,
Wang J.
,
Wang Q.
,
Williams G.A.
,
Wong G.K.-S.
,
Yao Z.
,
Zhang J.
,
Zhang X.
,
Zhao G.
,
Zhou J.
,
Zhou Y.
,
Nelson D.
,
Lehrach H.
,
Reinhardt R.
,
Naylor S.L.
,
Yang H.
,
Olson M.
,
Weinstock G.
,
Gibbs R.A.
more...
Nature440:1194-1198(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
2.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 107-286
tissue :
Hepatoma .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NOMENCLATURE;IDENTIFICATION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INDUCTION;INTERACTION WITH TP73
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]